Publications by authors named "N Borghol"

Article Synopsis
  • The study focuses on the spread of the Omicron variant of COVID-19, emphasizing the need for quick and effective detection methods.
  • Researchers designed a low-cost and fast RT-qPCR technique using SYBR Green to identify specific mutations in the Omicron variant, rather than relying on expensive genomic sequencing.
  • Testing of 120 clinical samples confirmed the presence of these mutations and validated the new detection method, which could help contain the spread of the variant in areas where it is prevalent.
View Article and Find Full Text PDF

Background: Breast cancer, the deadliest disease affecting women globally, exhibits heterogeneity with distinct molecular subtypes. Despite advances in cancer therapy, the persistence of high mortality rates due to chemotherapy resistance remains a major challenge. Lipoic acid (LA), a natural antioxidant, has proven potent anticancer properties.

View Article and Find Full Text PDF

Introduction: New fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages.

Methods: The synthesis of the designed molecules started from easily accessible and versatile -difluoro propargylic derivatives. The desired aromatic systems were obtained using Diels-Alder/aromatization sequences and this was followed by Pd-catalyzed coupling reactions and, when required, final functionalization steps.

View Article and Find Full Text PDF

Interleukin-21 (IL-21) is a cytokine with potent regulatory effects on different immune cells. Recently, IL-21 has been contemplated for use in the treatment of cancers. However, the molecular mechanisms regulating human IL-21 gene expression has not yet been described.

View Article and Find Full Text PDF

Chlorhexidine-Digluconate (CHX-Dg) is a biocide widely used as disinfectant or antiseptic in clinical and domestic fields. It is often found in the formulation of solutions to treat superficial wounds. Nevertheless, few studies have focused on its effects on while this bacterium is commonly involved in mixed infections.

View Article and Find Full Text PDF