Publications by authors named "N Bon"
Article Synopsis
- * Semen from various adult markhor males was collected via electro-ejaculation and successfully frozen using caprine methods, demonstrating good survival and fertility rates when tested with goat oocytes.
- * The research achieved the first successful blastocyst production in Tadjik markhor females through LOPU/IVF and successfully implemented intrauterine AI with frozen/thawed semen.
Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes.
Aging (Albany NY)
September 2023
Article Synopsis
- Senescent cells accumulate in osteoarthritis (OA) joint tissues due to injury, playing a role in OA development, but therapeutic approaches targeting these cells have been ineffective in human patients.
- This study developed models of chondrocyte senescence using etoposide to induce DNA damage-related senescence and chronic exposure to IL-1β for inflammation-related senescence.
- Etoposide effectively induces markers of cellular senescence, making it a reliable model for researching senescence in chondrocytes and could aid in developing therapies for OA.
Background: Osteoarthritis is an age-related disease that currently faces a lack of symptomatic treatment. Inflammation, which is mainly sustained by pro-inflammatory cytokines such as IL-1b, TNF, and IL-6, plays an important role in osteoarthritis progression. In this context, pro-inflammatory cytokines are widely used to mimic the inflammatory component of osteoarthritis in vitro.
View Article and Find Full Text PDFThe ability of a new compound, Wal, (walterolactone A/B 6--gallate-β-d-pyranoglucoside) originating from Champ. as a hydroperoxyl radical scavenger and pro-oxidant enzyme inhibitor was studied . Different mechanisms, reaction locations, and chemical species of Wal in aqueous solution were taken into consideration.
View Article and Find Full Text PDFOsteoporosis is characterized by low bone mineral density (BMD) and fragility fracture and affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of BMD, and its quantitative analysis is a major priority in osteoporosis research. Tissue mineralization is a fundamental process requiring calcium and phosphate transporters.
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