Publications by authors named "N Blatt"
Background: N6-methyladenosine (mA) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a mA demethylase. Given the important role of mA in biological mechanisms, mA and its regulators, have been implicated in many disease processes, including cancer.
View Article and Find Full Text PDFThe worldwide incidence rate of cancer of unknown primary (CUP) reaches 5% (Kang et al, 2021; Lee, Sanoff, 2020; Yang et al, 2022). CUP has an alarmingly high mortality rate, with 84% of patients succumbing within the first year following diagnosis (Registration and Service, 2018). Under normal circumstances, tumor cell metastasis follows the «seed and soil» hypothesis, displaying a tissue-specific pattern of cancer cell homing behavior based on the microenvironment composition of secondary organs.
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- Recent studies suggest that there may be a connection between lysosomal storage disorders (LSDs) and symptoms of schizophrenia (SCZ), indicating that lysosomal dysfunction could play a role in SCZ development.
- The research involved analyzing lysosomal enzyme activities and alpha-synuclein levels in blood samples from patients with late-onset SCZ and comparing them to patients with Parkinson's disease and healthy controls.
- Significant differences were found, including decreased enzyme activity, higher concentrations of certain lysosphingolipids, and genetic variants linked to LSDs in early-onset SCZ patients, which may contribute to understanding the overlap between these conditions.
The improvement of human living conditions has led to an increase in average life expectancy, creating a new social and medical problem-aging, which diminishes the overall quality of human life. The aging process of the body begins with the activation of effector signaling pathways of aging in cells, resulting in the loss of their normal functions and deleterious effects on the microenvironment. This, in turn, leads to chronic inflammation and similar transformations in neighboring cells.
View Article and Find Full Text PDFCoronavirus disease 2019 (COVID-19) affects several organs including the kidney resulting in acute kidney injury (AKI) and variants of podocytopathies. From the beginning to the middle period of the COVID-19 pandemic, we have collected eight renal biopsies with various renal diseases including 4 podocytopathies. In addition, from the middle period to the near end of the COVID-19 pandemic, we have seen two of the patients who developed nephrotic syndrome following COVID-19 vaccination.
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