Publications by authors named "N Bilen"
Bilateral epithelial keratopathy and punctate keratitis due to ribociclib.
J Oncol Pharm Pract
November 2024
Introduction: This report describes a rare occurrence of corneal epithelial keratopathy associated with ribociclib, a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor widely used in breast cancer treatment.
Case Report: An 83-year-old female with a recent breast cancer diagnosis presented with blurred vision during the third cycle of ribociclib treatment. Ocular examination revealed corneal epitheliopathy and fluorescein staining findings.
Background: The increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) infections among children represents a significant global concern, leading to elevated mortality rates. The aim of this study was to evaluate the risk factors, outcomes, 30-day mortality rates and contributing factors in children with CRE bloodstream infections (CRE-BSIs).
Methods: Data regarding demographic characteristics, treatment approaches and outcomes of hospitalized children aged 0-18 years diagnosed with CRE-BSIs between January 2018 and December 2022 were extracted from medical records.
Article Synopsis
- The study focuses on the challenges of treating cerebrospinal fluid (CSF) shunt infections in children, particularly those caused by gram-negative bacteria and the rise of carbapenem-resistant (CR) strains.
- It analyzed 64 infection episodes among 50 pediatric patients over a 10-year period, revealing that the majority were related to CSF shunt infections, with specific bacteria like Pseudomonas and E. coli being the most common culprits.
- The research identified risk factors for CR infections, such as prior carbapenem use and extended hospital stays, and found a concerning 30-day mortality rate that was notably higher in the CR group compared to non-CR patients.
Background: Bone and joint infections are common in children, particularly those under 10 years of age. While antimicrobial therapy can often successfully treat these infections, surgical drainage may also be necessary. It is important to note that prolonged courses of treatment have been associated with adverse events and drug reactions.
View Article and Find Full Text PDFBackground: This study focused on timelines of infection episodes and dominant variants and aims to determine disease severity and outcome of pediatric patients with reinfection.
Materials And Methods: This study retrospectively evaluated the medical records of the hospitalized patients and/or outpatients aged 0-18 with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction between March 2020 and September 2022 at Ege University Children's Hospital.
Results: Ninety-one pediatric patients reinfected with SARS-CoV-2 were included in the study.