Effective Reduction of Tau Amyloid Aggregates in the Presence of Cyclophilin from Pollens; An Alternative Mechanism of Action of the Allergen.

Background: A hallmark pathology of Alzheimer's disease (AD) is the construction of neurofibrillary tangles, which are made of hyperphosphorylated Tau. The cis-proline isomer of the pThr/Ser-Pro sequence has been suggested to act as an aggregation precursor according to the 'Cistauosis' hypothesis; however, this aggregation scheme is not yet completely approved. Various peptidyl-prolyl isomerases (PPIases) may specifically isomerize cis/trans-proline bonds and restitute Tau's ability to attach microtubules and may control Tau amyloid aggregation in AD.

Investigation of the urbanization contribution to the COVID-19 outbreak in Iran and the MECA countries.

The main objective of this research was to disclose the correlative contribution of urban-associated factors affecting the COVID-19 outbreak in the macro-scale of MECA countries and the downscaled micro-scale of the provincial divisions in Iran. For this purpose, the correlation coefficients between the variables and clustering analysis were used to expose the possible effects. Results revealed the comparatively strong relationships between some independent variables (e.

Molecular Genetic Analysis of α-Thalassemia in Hamadan Province, West Iran.

Identifying couples who are carriers of thalassemia-causing mutations, followed by prenatal diagnosis (PND), is undoubtedly an effective way to prevent the birth of children with the disease. Our aim in this study was to report for the first time the spectrum of α-globin gene mutations in the population living in Hamadan Province, West Iran. Multiplex gap-polymerase chain reaction (gap-PCR), amplification refractory mutation system (ARMS)-PCR, and direct DNA sequencing of and genes were used to identify the α-thalassemia (α-thal)-causing mutations in a cohort of 389 individuals including 328 α-thal carriers and 61 normal subjects.

Distribution of Gene Mutations in the Kurdish Population of Ilam Province, West Iran.

β-Thalassemia (β-thal) is one of the most common diseases in Iran. Here, we report the spectrum of gene mutations in 176 Kurdish β-thal carriers from the northern part of Ilam Province, Iran. The amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) technique was used to identify common β-globin gene mutations observed in Iran.

Synthesis and spectroscopic characterization of new sulfanilamide-functionalized magnetic nanoparticles, and the usability for carbonic anhydrase purification: is there perspective for 'cancer treatment' application?

This investigation indicated an efficient procedure to purify human carbonic anhydrase II (hCA II) enzyme through sulfanilamide-functionalized (γ-FeO-CPTES-SA) magnetic nanoparticles (MNPs), where synthesis of FeO MNPs was carried out using co-precipitation reaction. Next, 3-chloropropyltriethoxysilane (CPTES) was used to modify FeO nanoparticles and lastly, the surface of the nanoparticles was functionalized with sulfanilamide (SA) as a carbonic anhydrase ligand/inhibitor for binding to hCA II. The characterization of the synthesized nanoparticles was performed using various techniques.