Quality of life among geriatric population living with functional disabilities: A comparison between urban and rural populations of West Bengal.

Introduction: Global elderly population's growth is evident, with projections reaching 2 billion by 2050, while India's geriatric population is expected to rise to 11.6% by 2026. Disparity in quality of life (QOL) and disabilities between urban and rural elderly exist, where rural elderly maintain active roles, while urban counterparts face economic insecurity post retirement.

Human intraepithelial mast cell differentiation and effector function are directed by TGF-β signaling.

Mast cells (MCs) expressing a distinctive protease phenotype (MCTs) selectively expand within the epithelium of human mucosal tissues during type 2 (T2) inflammation. While MCTs are phenotypically distinct from subepithelial MCs (MCTCs), signals driving human MCT differentiation and this subset's contribution to inflammation remain unexplored. Here, we have identified TGF-β as a key driver of the MCT transcriptome in nasal polyps.

Study of a panel of genetic mutations in fibrocalcific pancreatic diabetes (FCPD): SPINK1 (N34S) mutation unlikely to be relevant.

Panel of known genetic mutations (SPINK1, PRSS1, PRSS2, CTRC, and CFTR) in patients with Fibrocalcific pancreatic diabetes (FCPD)compared to Type 2 Diabetes (T2DM) and healthy controls with emphasis on SPINK1 (N34S) mutations. Whole blood samples were used to detect mutations by PCR followed by Sanger sequencing. In-silico analysis of N34S performed, to explore role in pathogenesis.

New particle formation from isoprene under upper-tropospheric conditions.

Aircraft observations have revealed ubiquitous new particle formation in the tropical upper troposphere over the Amazon and the Atlantic and Pacific oceans. Although the vapours involved remain unknown, recent satellite observations have revealed surprisingly high night-time isoprene mixing ratios of up to 1 part per billion by volume (ppbv) in the tropical upper troposphere. Here, in experiments performed with the CERN CLOUD (Cosmics Leaving Outdoor Droplets) chamber, we report new particle formation initiated by the reaction of hydroxyl radicals with isoprene at upper-tropospheric temperatures of -30 °C and -50 °C.

Surgical treatment of coexisting intra and extralobar sequestration in an infant.

Pulmonary sequestration is a rare congenital malformation in which a nonfunctional segment of lung tissue has no communication with the tracheobronchial tree and does not participate in gas exchange. We present a rare case of a 20-month old female with extralobar pulmonary sequestration that was diagnosed at birth. The patient was also found to have a coexisting intralobar sequestration, found during surgery.