Publications by authors named "N Besnard"
Article Synopsis
- The study aimed to analyze the characteristics and outcomes of critically ill patients with severe pneumonia caused by SARS-CoV-2 across different pandemic waves, focusing on morbidity and mortality predictors.
- Conducted from March 2020 to October 2021, the study included 437 adult patients and found that ICU mortality decreased from 26% in the first wave to around 10% in later waves, with factors like age and comorbidities influencing death risk.
- The research concluded that overall survival improved due to the effects of interventions like vaccination and dexamethasone, although bronchopulmonary aspergillosis increased mortality risk significantly to 36%.
Article Synopsis
- Tubular injury is identified as the primary cause of acute kidney injury (AKI) in critically ill patients with COVID-19, with proximal tubular dysfunction (PTD) and specific urinary biomarkers potentially indicating AKI before it occurs.
- A study analyzing 60 ICU COVID-19 patients revealed that 48% had PTD, 55% developed AKI, and 33% experienced persistent AKI, with urinary NGAL being the most effective biomarker for predicting these conditions.
- The findings highlight that while PTD and AKI were common among patients, higher levels of the simplified acute physiology score (SAPSII) and certain medical treatments contributed significantly to the risk of AKI.
Objectives: The use of extended intermittent infusion (EII) or continuous infusion (CI) of meropenem is recommended in intensive care unit (ICU) patients, but few data comparing these two options are available. This retrospective cohort study was conducted between 1 January 2019 and 31 March 2020 in a teaching hospital ICU. It aimed to determine the meropenem plasma concentrations achieved with CI and EII.
View Article and Find Full Text PDFA LiPSCl-rich composite is prepared using a PEG-borate ester solid-state polymer electrolyte (BSPE). BSPE is a highly accessible compound with high ionic conductivity and excellent electrochemical stability against Li metal. Thereby, the stability of the LiPSCl-rich composite with BSPE improved significantly.
View Article and Find Full Text PDFBackground: A higher sodium (Na) dialysate concentration is recommended during renal replacement therapy (RRT) of acute kidney injury (AKI) to improve intradialytic hemodynamic tolerance, but it may lead to Na loading to the patient. We aimed to evaluate Na flux according to Na dialysate and infusate concentrations at 140 and 145 mmol/L during hemodialysis (HD) and hemodiafiltration (HDF).
Methods: Fourteen AKI patients that underwent consecutive HD or HDF sessions with Na dialysate/infusate at 140 and 145 mmol/L were included.