Publications by authors named "N Berghmans"
Macrophage activation syndrome (MAS) exemplifies a severe cytokine storm disorder with liver inflammation. In the liver, classical natural killer (cNK) cells and liver-resident type 1 innate lymphoid cells (ILC1s) dominate the ILC population. Thus far, research has primarily focused on the corresponding role of cNK cells.
View Article and Find Full Text PDFMultiple sclerosis (MS) is a neurodegenerative, autoimmune disease that is still incurable. Nowadays, a variety of new drugs are being developed to prevent excessive inflammation and halt neurodegeneration. Among these are the inhibitors of Bruton's tyrosine kinase (BTK).
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- Interferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) functions as a chemokine that attracts activated T and NK cells by binding to its receptor CXCR3, although its natural posttranslational modifications, especially at the C-terminus, have not been fully understood.
- Research involved analyzing synovial fluid from rheumatoid arthritis patients to compare the levels of natural and intact CXCL10 using mass spectrometry and various biological assays to assess its effects on cell behavior.
- Findings revealed that natural CXCL10 was more prevalent and had reduced binding affinity for glycosaminoglycans and weaker signaling capabilities, indicating its diminished effectiveness in promoting immune cell migration and activation
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- Primary ciliary dyskinesia (PCD) is a genetic disorder that causes repeated airway infections, and there are currently no specific treatments available for it.
- This study analyzed neutrophils (a type of immune cell) from both the sputum of PCD patients and their blood, finding that sputum neutrophils were highly activated but were unresponsive to normal stimuli.
- The research suggests that dysfunctional neutrophils in PCD may worsen inflammation in the airways, and further studies should explore anti-inflammatory treatments and ways to enhance the clearance of dead cells.
Acute respiratory distress syndrome (ARDS) consists of uncontrolled inflammation that causes hypoxemia and reduced lung compliance. Since it is a complex process, not all details have been elucidated yet. In a well-controlled experimental murine model of lipopolysaccharide (LPS)-induced ARDS, the activity and viability of macrophages and neutrophils dictate the beginning and end phases of lung inflammation.
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