Publications by authors named "N Bengani"
Article Synopsis
- The study examines how food restriction (FR) affects levels of plasma corticosterone (B), adrenocorticotropic hormone (ACTH), and proopiomelanocortin (POMC) in Fischer 344 rats.
- Rats on FR showed a significant increase in plasma B levels in the afternoon, while ACTH levels were lower in the morning but consistent in the evening compared to ad libitum (AL) rats.
- The research findings suggest that the lower ACTH in FR rats may be due to their higher corticosterone levels, and indicate that the regulation of POMC and ACTH is distinct in the context of food restriction.
Recent reports have demonstrated that the secretion of ACTH from sheep anterior pituitary primary cultures is markedly stimulated by arginine vasopressin (AVP) but not by CRF, and that AVP-stimulated ACTH secretion is potentiated by CRF. It has also been reported that AVP increases total ACTH content (secreted plus intracellular ACTH), suggesting that AVP stimulates POMC biosynthesis in the ovine anterior pituitary. These observations differ from the rat, in which CRF is the most potent of the ACTH-releasing factors and the only ACTH secretagogue which stimulates POMC gene expression and biosynthesis.
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