Hyperthyroidism induced by Graves' disease reversibly affects skin microvascular reactivity.

Background: The impact of hyperthyroidism induced by Graves' disease (GD) on skin microcirculation has not been established. We aimed to assess vascular reactivity in hyperthyroid GD patients before and during treatment.

Methods: Laser Doppler flux (LDF) was measured in 31 newly diagnosed hyperthyroid GD patients with an increased TSH receptor stimulating antibody (TSAb) levels before the methimazole treatment; and again 5.

Comparison of antihyperglycemic effects of creatine and metformin in type II diabetic patients.

Purpose: To compare the antihyperglycemic effects of metformin and creatine in recently detected type II diabetics in a short-term clinical study.

Methods: In a 14 day simmetrically randomized crossover study, recently detected type II diabetics received either creatine (2x3 g/day) or metformin (2x500 mg/day) for five days, followed by two days of washout, followed by cross-over to the opposite treatment for the next five days. Fasting and post-prandial (-15, 60, 90, 120, 180 and 240 min) blood glucose, insulin, c-peptide, creatine and lactate were measured every other day for the duration of treatment, and HbA1c only at the begining and at the end of the study.