Publications by authors named "N Balachandran"
Introduction: The 1985 Hames Consortium convened family medicine researchers to identify outstanding questions in their practice.
Method: In this descriptive review, we collected, codified, and analyzed available literature to describe the availability of evidence to answer these questions.
Results: Of 136 total questions, researchers rated 33 questions as not at all answered (24.
Objectives: To evaluate the tolerability of crovalimab versus eculizumab in C5 inhibitor (C5i)-naive and -experienced patients with PNH from COMMODORE 2, 3 and 1 (NCT04434092, NCT04654468 and NCT04432584).
Methods: Pooled safety data were assessed in the total crovalimab and eculizumab populations and by C5i-naive versus C5i-switched status in patients receiving crovalimab. Analyses include 6.
Article Synopsis
- Phyllodes tumours are rare breast tumors, making up only 1% of breast tumors, characterized primarily by their fibroepithelial composition.
- A 20-year-old woman experienced significant growth in a borderline phyllodes tumor, which led to multiple surgeries, including a mastectomy, due to metastasis and persistent recurrence.
- Despite aggressive treatment including surgery, radiotherapy, and chemotherapy, the patient's condition worsened, highlighting the importance of obtaining clear surgical margins to reduce recurrence risks.
Background: While enteric viruses are highly transmissible, household factors associated with transmission are less well documented. We identified individual- and household-level factors associated with viral acute gastroenteritis (AGE) transmission in a large health care network in the United States.
Methods: Patients presenting with AGE were enrolled from April 2014 to September 2016.
Article Synopsis
- Adenovirus has been linked to hepatitis in immunocompromised children, but not typically in healthy ones; this changed in April 2022 when unexplained hepatitis cases surfaced in the USA and UK, prompting national surveillance by the CDC.
- The study focused on children under 10 with unexplained hepatitis and elevated liver enzymes, collecting detailed medical data, caregiver interviews, and specimen testing to identify causes.
- A total of 377 cases were documented from October 2021 to September 2022, with a median patient age of 2.8 years and a fairly equal distribution of males and females.