Publications by authors named "N Bakewell"
Objectives: The survival rate of people with HIV admitted to intensive care units (ICUs) is approaching that of people without HIV. We conducted a matched-cohort study of people with and without HIV admitted to ICU at a large hospital to compare short-term mortality, during 2000-2019.
Methods: People with HIV were matched to people without HIV (1:2) on age, sex, admission year and Acute Physiology and Chronic Health Evaluation (APACHE)-II score.
Article Synopsis
- People with HIV (PWH) admitted to ICUs have a higher risk of mortality, with this study analyzing data from 2000-2019 to focus on 1-year post-ICU admission mortality trends.
- Among 221 PWH admitted, 108 died within a year, but the overall 1-year mortality risk decreased by 10% annually, adjusted to 7% when accounting for various factors like age and CD4+ count.
- The findings stress a decline in post-ICU mortality rates over time, indicating a need for further research and ongoing care support for PWH after they're discharged from the hospital.
Background: Hepatic steatosis is a major cause of chronic liver disease associated with several negative health outcomes. We compared the prevalence of and factors associated with steatosis in people living with and without HIV.
Methods: Older (>50 years) and younger (<50 years) people with HIV and older HIV-negative controls (>50 years) underwent liver transient elastography examination with controlled attenuation parameter (steatosis ≥238 dB/m, moderate/severe steatosis ≥280 dB/m, liver fibrosis ≥7.
Article Synopsis
- The study analyzes ICU admission outcomes for people with HIV (PWH) at a UK referral center from 2000 to 2019, highlighting a significant decrease in mortality rates over the years.
- Among 221 PWH, the study found in-ICU mortality at 29% and in-hospital mortality at 38.5%, with lower respiratory tract infections being the most common reason for admission.
- Despite adjustments for various patient factors, mortality rates continued to decline, suggesting improvements in critical care and patient health due to advances in treatment.
People living with HIV are at increased risk for depression, though the underlying mechanisms for this are unclear. In the general population, depression is associated with peripheral and central inflammation. Given this, and since HIV infection elicits inflammation, we hypothesised that peripheral and central inflammatory biomarkers would at least partly mediate the association between HIV and depressive symptoms.
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