Publications by authors named "N Baik"
The plasminogen receptor, Plg-R is a unique cell surface receptor that is broadly expressed in cells and tissues throughout the body. Plg-R localizes plasminogen on cell surfaces and promotes its activation to the broad-spectrum serine protease, plasmin. In this study, we show that overexpression of Plg-R protects mice from high fat diet (HFD)-induced adipose and metabolic dysfunction.
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- * A study found that lower levels of plasminogen (Plg) are linked with more severe sepsis, while higher levels of IL-6, a sepsis severity marker, are observed; there’s a negative correlation between Plg and IL-6 in both mice and humans.
- * Deficiency of Plg made mice more vulnerable to less severe forms of sepsis, leading to more severe inflammation and organ damage, while introducing plasminogen or its active form improves survival and reduces inflammation-related damage.
The plasminogen activation system regulates the activity of the serine protease, plasmin. The role of plasminogen receptors in cancer progression is being increasingly appreciated as key players in modulation of the tumor microenvironment. The interaction of plasminogen with cells to promote plasminogen activation requires the presence of proteins exposing C-terminal lysines on the cell surface.
View Article and Find Full Text PDFMachine intelligence can convert raw clinical data into an informational source that helps make decisions and predictions. As a result, cardiovascular diseases are more likely to be addressed as early as possible before affecting the lifespan. Artificial intelligence has taken research on disease diagnosis and identification to another level.
View Article and Find Full Text PDFBackground: Plg-R , a unique transmembrane plasminogen receptor, enhances the activation of plasminogen to plasmin, and localizes the proteolytic activity of plasmin on the cell surface.
Objectives: We investigated the role of Plg-R in adipose function, metabolic homeostasis, and obesity.
Methods: We used adipose tissue (AT) sections from bariatric surgery patients and from high fat diet (HFD)-induced obese mice together with immunofluorescence and real-time polymerase chain reaction to study adipose expression of Plg-R .