Publications by authors named "N B Loan"
A comprehensive computational strategy that combined QSAR modelling, molecular docking, and ADMET analysis was used to discover potential inhibitors for β-secretase 1 (BACE-1). A dataset of 1,138 compounds with established BACE-1 inhibitory activities was used to build a QSAR model using mol2vec descriptors and support vector regression. The obtained model demonstrated strong predictive performance (training set: = 0.
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- - The study examined how nutrition-related symptoms affect the quality of life (QoL) for advanced non-small cell lung cancer (NSCLC) patients, using assessments like the PG-SGA and EORTC QLQ-LC13 tools.
- - Data was collected from 170 patients undergoing chemotherapy, revealing that poor nutritional status is significantly linked to a decline in QoL.
- - While some symptoms, like cough and shortness of breath, showed a moderate positive correlation with nutritional assessments, many other symptoms had weak correlations, indicating that focusing solely on nutrition may not sufficiently improve QoL for these patients.
Surface-enhanced Raman scattering (SERS) is a powerful, highly efficient analytical technique capable of providing label-free, non-invasive, rapid, and ultrasensitive molecular detection down to the single-molecule level. Despite its advantages, SERS remains largely confined to laboratory settings due to the complexities of substrate fabrication and challenges in analyzing real-world samples. Developing flexible SERS substrates that achieve both high fabrication efficiency and high sensing performance, while being practical for field applications, is critical for advancing SERS toward broader, real-world use.
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- Researchers developed Au-NiFeO hetero-nanostructures (Au-NFO HNs) as an effective photoactive material for a photoelectrochemical sensor aimed at detecting paracetamol (PCM) using visible light.
- The interaction between gold nanoparticles (Au NPs) and nickel iron oxide nanofibers (NFO NFs) creates a built-in electric field that enhances electron migration, improves photocatalytic activity, and minimizes the recombination of electron-hole pairs.
- The Au-NFO HNs-based sensor demonstrates high sensitivity (1.089 µA/µM/cm), a broad detection range (0.5-200 µM), and low detection limits (0.38 µM), while showing
Purpose: Standard oral cancer chemotherapy (OCT) or targeted therapy (OTT) has expanded the treatment methods for hepatocellular carcinoma (HCC). However, its principal nonadherence causes a reduction in efficacy. We aimed to evaluate the status of nonadherence and influencing factors among outpatient patients with HCC.
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