[Changes in the properties of the brain opiate, DA2, GABA, and 5-HT1 receptors in the progeny of female rats consuming ethanol for a long time during pregnancy and lactation].

The study was undertaken to examine two-week and two-month rats whose mothers had been given alcohol for a long period of time during pregnancy and lactation. Profound changes were found in the properties of all types of the receptors under study. The changes were found in the receptors of both group animals.

[The biological mechanisms of a congenital predisposition to alcoholism].

In descendants of white rats with chronic alcoholic intoxication, the contents of DA in the brain and blood plasma, characteristics of GABA and opiate brain receptors, the contents of cAMP and other substances were studied as well as the c-fos gene expression. The data obtained suggest a considerable role of the changes in the DA system functions in the genesis of pathology in these descendants.

[Changes in the properties of the 5-HT1 receptors in the brains of rats, the progeny of parents consuming morphine for a long time].

Studies were performed in two-month rats whose parents had been given morphine for a long period before mating. Considerable changes were found in the properties of rat brain 5-HT1 receptors, which manifested as increased number of ligand binding sites (Bmax) and higher KD, which indicates a lower receptor affinity for ligand. Single morphine administration to the animals caused normalization of the properties of the receptors.

[The action of low doses of bromocryptin in experimental morphine abstinence in rats].

In experiments on rats which consumed for a long time morphine solution as a drinking liquid there was studied the effect of low doses of bromocriptine on the behavioural manifestations of morphine abstinence syndrome and the condition of the noradrenergic, dopaminergic and conjugated GABAergic systems of the brain. It was shown that the preliminary administration of bromocriptine decreased the degree of the withdrawal syndrome that correlated with the restoration of dopamine content and the normalization of the condition of D2-dopaminergic receptors in different regions of the brain. Bromocriptine exerted no influence on the morphine withdrawal-induced changes in the condition of GABA receptors of the cerebral cortex.