[Effect of clonazepam and antiarrhythmic drugs on heart rate variability in patients with paroxysmal atrial fibrillation].

Aim: To study direction and intensity of autonomic changes in patients with paroxysmal atrial fibrillation (PAF) treated with clonazepam and their dynamics during antiarrhythmic therapy.

Material: Patients with nonrheumatic PAF during effective clonazepam monotherapy or ineffective antiarrhythmic therapy (n=95), untreated patients with PAF (n=22), healthy persons (n=10).

Methods: Clinical cardiological and neurological examination, assessment of the state of autonomic nervous system, emotional sphere, patterns of sleep, and spectral analysis of heart rate variability (HRV).

[Spectral analysis of heart rate variability in diagnosis of vegetative autonomic dysfunction in patients with attacks of atrial fibrillation.].

Aim: Elucidation of possible role of suprasegmental and segmental autonomic vegetative disturbances in pathogenesis of paroxysmal atrial fibrillation.

Material: Untreated patients (n=22) with nonrheumatic paroxysmal atrial fibrillation and 10 healthy subjects.

Methods: Clinical cardiological and neurological examination, assessment of the state of vegetative nervous system, emotional sphere, patterns of sleep, and spectral analysis of heart rate variability.

[The nature of very low frequency component of the heart rate variability and the role of sympathetic-parasympathetic interactions].

A method of separate monitoring "instant" changes of the VLF, LF and HF power spectral components of heart rate variability, has been developed. The power of the LF and HF spectral components were proved to be continuously changing. The period of these power fluctuations could stay within 15 to 150 sec.

[Variability of heart rhythm in dynamic study of the psychovegetative relationship in neurogenic syncope].

Physiological changes accompanying syncopes of neural origin (SNO) in patients with psychovegetative syndrome are still insufficiently studied. The data concerning the role of the autonomic nervous system are discrepant. Heart rate variability was analyzed in 68 patients with SNO in a supine position and during the active 20-min orthostatic test taking into account the heart rate components of very low frequency (VLF, an index of cerebral sympathetic activity) and high frequency (HF, a marker of vagal modulation).

[The role of clinical-electrophysiological indices in therapy for late-stage residual stroke by dynamic correction of proprioception].

The new method dynamic proprioceptive correction using a medical loading costume was included into complex therapy in patients with late-stage residual stroke. Application of the costume promoted normalization of complex locomotor acts of walking by correcting proprioceptive pulsation resulted from the system of elastic draughts. Thus, a new motor stereotype was forced upon the patients.