[Ultrastructural changes in plague microbes of vaccinal strain EB and alveolar macrophages of guinea pigs during their interaction in vitro].

Aerosol immunization with plague vaccine EB was found to stimulate an increase in the number of free alveolar macrophages and to enhance their ingesting activity which correlated with an increase in specific antibody titers. Immunological transformation was accompanied by ultrastructural changes in the cytoplasm and the nuclei of alveolar macrophages. The phagocytosis of microbes occurred by their adsorption onto the microphage surface, invagination and enclosing into the endocytic bubble having the function of the digestive vacuole.

[Electron microscopic study of the small intestine in experimental cholera].

Ultrastructure of the small intestine was studied in nursling rabbits infected with the El Tor 5879 vibrio culture. Cholera vibrio was localized in the intestinal lumen mostly in the crypts area, in some places adhering to the brush edge of enterocytes without penetrating them. Epithelium of the villae remained intact; it however displayed dystrophic changes of microvilli and organoids, cytoplasma vacuolization and increase in lysosome count.

[Ultrastructure of parasitic forms of the agent of coccidioidomycosis].

The authors studied the ultrastructure of the Coccidiodes immitis spherules in the sections of the abdominal cavity foci and pneumonic foci of Cricetus auratus W. and in albino mice infected intraperitoneally with a lethal dose of the mycelium fungus phase. It was found that the spherules of coccidiod fungus represented multinuclear cells with a well-organized protoplast included into a complicated supermembrane structure--the cell wall.