Gaseous superoxide potentiation of the effect of nonnarcotic analgesics in low doses.

The action of inhalation of gaseous superoxide on the effects of low doses of nonnarcotic analgesics was studied on volunteers in the little finger compression test. After administration of placebo, inhalation of gaseous superoxide produced a negligible transient decrease in pain tolerance threshold. Inhalation of gaseous superoxide potentiated the effects of threshold doses of novalgin and aspirin and prolonged their action, but did not modulate the analgesic effect of diclofenac.

[Changes in protein, lipid composition, DNA- and RNA- polymerase activity of the chromatin fraction and the nuclear matrix of the rat liver in hypovitaminosis E].

E-hypovitaminosis-induced antioxidant deficiency in rats causes changes in some properties of nuclear structures of the liver cells, i.e. fractions of transcriptionally active and repressed chromatin and nuclear matrix.

[Lipid peroxidation and parameters of thermodenaturation of chromatin fractions in the rat liver].

The fractions of transcriptionally active and repressed chromatin of the rat liver include lipids, whose fatty acid residues are the substrates of lipid peroxidation (LP) processes. In vitro incubation in NADPH- and ascorbate-dependent LP systems resulted in the activation of peroxidation in the liver chromatin of intact animals, estimated from malonic dialdehyde (MDA) accumulation, the LP processes proceeding more intensely in the fractions of transcriptionally active vs. repressed chromatin.

[Functional activity of fractionated chromatin from rat liver upon a single administration of carbon tetrachloride].

Functions of rat liver cell genome were distinctly altered after a single administration of tetrachloromethane into animals. Maximal alterations in the structure-functional properties of chromatin were detected within 2 hrs after intoxication. The phenomenon was accompanied by the following shifts in the chromatin active fractions: activation of DNA- and RNA polymerases, decrease in content of this fraction, increase in the ratio protein/DNA due to elevation in the protein component with molecular mass 65 kDa detected in the nonhistone fraction of electrophoretogram.