Publications by authors named "N B Demina"
Xyloglucan is a highly promising 'green' polymer that has found its application in the food and pharmaceutical industries. Due to its molecular structure similarity to mucin, it has remarkable mucoadhesion properties, which has led to a high research interest in this excipient for the development of transmucosal delivery systems. Thermosensitivity is another promising property of xyloglucan derivatives, which is mainly exhibited by synthetic block copolymers such as pluronics and PLGA derivatives.
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- New drug delivery systems that respond to stimuli have been created for injections, focusing on using smart polymers that change at the injection site.
- Sterility is crucial for all injectable and eye medication forms, and choosing the right sterilization method is key, as it can alter the drug’s properties.
- There is a lack of research on the risks of sterilizing these sensitive systems, but this review offers recommendations based on existing experimental data to help manage these risks.
oculocutaneous albinism (OCA) is a hereditary impairment of skin, hair, and eye pigmentation. The most common form of albinism is autosomal recessive albinism, caused by mutations in the gene, accounting for approximately 40-50% of all cases of the disease in European populations. Common hypomorphic variants in the gene could lead to a mild form of albinism in a compound heterozygous state with a pathogenic variant.
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- Recent research shows ribavirin can effectively treat glioblastoma using an intranasal delivery method that targets the brain directly.
- The study focused on improving ribavirin's bioavailability by using gel-forming polymers in the nasal cavity, incorporating thermosensitive, pH-sensitive, and ion-selective materials.
- The optimal gel composition was determined as 0.5% gellan gum, 2% Poloxamer 124, and a 100 mg/mL concentration of ribavirin, and in vivo tests demonstrated successful drug penetration into the brain via the olfactory pathways in male rats.
Ribavirin has been used as an antiviral agent to treat a variety of viral infections since the 1970s. Over the past few decades, studies have been conducted on the pharmacology of ribavirin, and the possibility of its use in new indications has been explored. According to the results of a number of studies, ribavirin efficacy in the therapy of malignant neoplasms of various genesis has been proven.
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