Lipoamide influences substrate selection in post-ischaemic perfused rat hearts.

We investigated whether lipoamide and diacetyl-lipoamide are able to change the substrate selection in post-ischaemic myocardium. This can be important, because shifting heart metabolism from fatty acid to carbohydrate oxidation can decrease ischaemic injury. Studying the metabolism of [1,2-13C]diacetyl-lipoamide in situ in perfused rat heart by 13C n.

Effect of lidocaine on contracture, intracellular sodium, and pH in ischemic rat hearts.

The relationships among intracellular Na concentration ([Na+]i), intracellular pH, [ATP], and contracture during global ischemia were studied in isolated, perfused rat hearts. Intracellular Na was monitored by 23Na nuclear magnetic resonance (NMR) spectroscopy using thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylene phosphonate) (TmDOTP5-) as the paramagnetic shift reagent. High-energy phosphates and pH were monitored under the same conditions using 31P-NMR spectroscopy.

Influence of cardiac pacing on intracellular sodium in the isolated perfused rat heart.

Increased myocardial contractile tension has been described as being associated with increased heart rate. This phenomenon is believed due to greater sodium influx than efflux, resulting in accumulation of intracellular sodium. Sodium-23 nuclear magnetic resonance spectroscopy in combination with extracellular shift reagents offers near-continuous measurements of intracellular sodium that may be correlated with mechanical performance.

Primary treatment of regional and disseminated pancreatic cancer with hexamethylmelamine, mitomycin C and 5-fluorouracil infusion.

Hexamethylmelamine, mitomycin C and 5-fluorouracil infusion (HexMF) achieved a median survival of 9 months for the 45 patients with either metastatic stage III or unresectable stage II carcinoma of the pancreas. Fifteen percent survived 2 years. Of 32 patients with measurable tumors, 7 had partial and 3 had minor responses (31%); an additional 44% has stable disease for 3 months or more.