Producing a tissue-engineered pancreas based on a tissue-specific scaffold from a decellularized pancreas, imitating the natural pancreatic tissue microenvironment and the islets of Langerhans, is one of the approaches to treating patients with type 1 diabetes mellitus (T1DM). The aim of this work was to investigate the ability of a fine-dispersed tissue-specific scaffold (DP scaffold) from decellularized human pancreas fragments to support the islets' survival and insulin-producing function when injected in a streptozotocin-induced diabetic rat model. The developed decellularization protocol allows us to obtain a scaffold with a low DNA content (33 [26; 38] ng/mg of tissue, < 0.
View Article and Find Full Text PDFObjective: To evaluate the main modifiable risk factors for ischemic stroke (IS) and features of the course in atherothrombotic, cardioembolic, and lacunar subtypes of IS in men aged 18-50 years.
Material And Methods: The study included 125 men (the mean age was 42.6±5.
The red king crab, , was introduced into the Barents Sea where, after a period of 30 years of adaptation, it has established a new population. This population has been commercially exploited over the past two decades, supporting profitable fisheries in both Russia and Norway. Biochemical studies aimed at assessing fatty acid profiles have been conducted, focusing primarily on the edible parts of red king crabs.
View Article and Find Full Text PDFTi-TiN-(Y,Ti,Al)N coatings with a three-layer architecture (adhesive Ti layer, transition TiN layer, and wear-resistant (Y,Ti,Al)N layer) were studied. When depositing coatings, three arc current values of the yttrium cathode were used: 65, 85, and 105 A. The yttrium contents in the coatings were 30, 47, and 63 at.
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