Publications by authors named "N Aytan"
Neurodegeneration is a seminal feature of many neurological disorders. Chronic traumatic encephalopathy (CTE) is caused by repetitive head impacts (RHI) and is characterized by sulcal tau pathology. However, quantitative assessments of regional neurodegeneration in CTE have not been described.
View Article and Find Full Text PDFBackground: Protein biomarkers have been broadly investigated in cerebrospinal fluid and blood for the detection of neurodegenerative diseases, yet a clinically useful diagnostic test to detect early, pre-symptomatic Alzheimer's disease (AD) remains elusive. We conducted this study to quantify Aβ40, Aβ42, total Tau (t-Tau), hyperphosphorylated Tau (ptau181), glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) in eye fluids relative to blood.
Methods: In this cross-sectional study we collected vitreous humor, aqueous humor, tear fluid and plasma in patients undergoing surgery for eye disease.
Article Synopsis
- Parkinsonism is often linked to chronic traumatic encephalopathy (CTE) caused by repetitive head injuries, but the exact causes of parkinsonism in CTE patients are not fully understood.
- This study examined brain donors diagnosed with CTE to determine how often parkinsonism occurs and its relationship with brain damage due to past sports-related injuries.
- Results indicated that 24.7% of CTE participants experienced parkinsonism, which was associated with older age, higher dementia rates, and more severe stages of CTE, suggesting a significant connection between the severity of CTE and parkinsonism.
The purpose of this study is to investigate and analyze new concentric-zonal color effects in polyphase ceramic samples, particularly in a ceramic sample obtained from coal ash in the Ekibastuz coal basin. The study aims to explore the nature and characteristics of these color bands through x-ray fluorescence analysis, and provide a qualitative and quantitative analysis of the obtained x-ray fluorescence spectra. This paper presents the results of the study of new volume-surface concentric-zonal color effects in polyphase ceramic samples.
View Article and Find Full Text PDFBackground: Multiple studies have reported brain lipidomic abnormalities in Alzheimer's disease (AD) that affect glycerophospholipids, sphingolipids, and fatty acids. However, there is no consensus regarding the nature of these abnormalities, and it is unclear if they relate to disease progression.
Objective: Monogalactosyl diglycerides (MGDGs) are a class of lipids which have been recently detected in the human brain.