Publications by authors named "N Ayalon"
Retrieval of Embolized WATCHMAN Flex Atrial Appendage Occlusion Device.
Vasc Endovascular Surg
October 2024
This case report documents the management of a 66-year old man with atrial fibrillation with recent placement of a WATCHMAN Flex atrial appendage occlusion device. The patient presented with renal failure, abdominal pain, and difficulty walking 2 months after placement. The WATCHMAN Flex device was found to have embolized to his abdominal aorta at the level of the renal arteries with associated thrombus.
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- The American Heart Association's "ideal cardiovascular health" (CVH) framework identifies modifiable risk factors to lower the risk of cardiovascular disease (CVD), and metabolomics can reveal connections between these factors and CVD development.
- A study involving 3,056 adults showed that CVH scores were linked to various metabolites that were also associated with the risk of atrial fibrillation (AF) and heart failure (HF), emphasizing that certain metabolites mediate this connection.
- Specifically, three metabolites significantly mediated the link between CVH scores and AF, while seven metabolites partially mediated the association with HF, highlighting important metabolic pathways involved in cardiovascular health.
Article Synopsis
- The study aimed to create a systematic protocol for dissecting and preserving human hearts to improve biobanking for cardiovascular research, expanding on previous transcriptomics work.
- Current cardiac biobanks are limited, mostly housing biopsy tissues, which makes it hard to link full organ conditions with clinical data.
- Findings showed that RNA and metabolite stability were maintained for up to 12 hours after death, indicating the potential for high-quality multiomics data essential for understanding human cardiovascular disease (CVD).