Publications by authors named "N Asoh"
Introduction: Controlling pulmonary complex (MAC) disease is difficult because there is no way to know the clinical stage accurately. There have been few attempts to use cell-mediated immunity for diagnosing the stage. The objective of this study was to characterize cytokine profiles of CD4+T and CD19+B cells that recognize various -associated antigens in different clinical stages of MAC.
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- The study compared IgG antibody levels against the SARS-CoV-2 receptor binding protein in people with and without previous infections after mRNA vaccinations for up to 48 weeks.
- It found that those with previous infections had consistently higher antibody levels after two vaccine doses compared to those without prior infection.
- Both groups saw improved antibody responses after receiving a booster shot, emphasizing the importance of boosters for those with previous infections.
Background: Pediatric pneumococcal conjugate vaccines (PCVs) introduction has directly and indirectly reduced pneumococcal pneumonia and invasive disease caused by PCV-covered serotypes among children and adults globally. In Japan, both PCV7 and PCV13 were introduced into the national immunization program (NIP) for children in 2013. However, the long-term impact of PCV use in children on adult pneumococcal pneumonia in Japan remains unclear.
View Article and Find Full Text PDFBackground: Multiple serotypes of pneumococci have epidemiological and clinical implications, such as the emergence of non-vaccine serotypes and the acquisition of antimicrobial resistance. Prevalence of multiple serotypes of pneumococci in adults and their risk factors are not known.
Methods: We enrolled adult patients from age ≥15 years with radiologically confirmed pneumonia in four hospitals across Japan.