Publications by authors named "N Asahara"
Article Synopsis
- HDL (high-density lipoprotein) has protective effects against cerebral infarction due to its antioxidant, anti-inflammatory, and antithrombotic properties, but there's a lack of effective clinical treatments.
- Researchers focused on paraoxonase 1 (PON1), an enzyme linked to HDL, to develop it as a new therapy for ischemia-reperfusion injury in stroke.
- The study found that PON1 can effectively bind to HDL, reduce infarct volume in a mouse model, and improve neurological function, suggesting its potential as a treatment for acute stroke.
Adiponectin receptors, AdipoR1 and AdipoR2 are promising targets for the prevention and treatment of metabolic diseases. In this study, we aimed to establish agonistic antibodies against AdipoR1 and AdipoR2 with a long enough half-life to provide a means of improving poor medication adherence associated with preclinical small-molecule AdipoR agonists or existing antidiabetic drugs. Monoclonal antibodies were obtained by immunizing AdipoR knockout mice with human AdipoR-expressing cells.
View Article and Find Full Text PDFSome cases of endometrial cancer are associated with a familial tumor and are referred to as hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Lynch syndrome is thought to be induced by germline mutation of the DNA mismatch repair (MMR) gene. An aberration in the MMR gene prevents accurate repair of base mismatches produced during DNA replication.
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