Paclitaxel/epigallocatechin gallate coloaded liposome: a synergistic delivery to control the invasiveness of MDA-MB-231 breast cancer cells.

Matrix metalloproteinases (MMPs) have been investigated as a potential target for treating invasive breast cancers. The chemotherapy for breast cancer is often prescribed as a combination of drugs. The present study investigates a novel strategy of combining a MMP inhibitor, Epigallocatechin gallate (EGCG), along with an anticancer drug, Paclitaxel (PTX), in the form of a liposomal co-delivery system.

Hybrid biogeography based simultaneous feature selection and MHC class I peptide binding prediction using support vector machines and random forests.

Accurate detection of peptides binding to specific Major Histocompatibility Complex Class I (MHC-I) molecules is extremely important for understanding the underlying process of the immune system, as well as for effective vaccine design and developing immunotherapies. Development of learning algorithms and their application for binding predictions have thus speeded up the state-of-the-art in immunological research, in a cost-effective manner. In this work, we propose the application of a hybrid filter-wrapper algorithm employing concepts from the recently developed biogeography based optimization algorithm, in conjunction with SVM and Random Forests for identification of MHC-I binding peptides.

Heavy metal removal from copper smelting effluent using electrochemical cylindrical flow reactor.

The purpose of this study is mainly to evaluate the performance of the continuous recirculation flow cell at low current density and pH (the pH at which the effluents are available) in removing heavy metals from copper smelting effluent by cathodic reduction. During the electrolysis at different pH, % removal of heavy metals removal, energy consumption and heterogeneous reaction rate constants were investigated at given flow rate and current density on the selected industrial effluent. The overall specific energy consumption at the pH 0.

L-glutamic acid production in a novel three phase fluidized bed reactor using coimmobilized bio-catalyst.

The production of L-Glutamic acid has been studied using coimmobilized whole cells of pseudomonas reptilivora and micrococcus glutamicus in a three phase fluidized bed bioreactor with selected production medium enriched with glucose. The effect of initial substrate concentration, temperature, pH and aeration rate on the yield of glutamic acid has been investigated. It has been found that the acid production increases exponentially with substrate concentration and mass transfer co-efficient varied linearly with temperature and aeration rate.