Influencing factors and changing trends of depressive symptoms among middle and junior high school students in Eastern China from 2019 to 2023: a cross-sectional study.

Background: The emergence of the COVID-19 pandemic led to increased levels of depression among adolescents in 2019. However, the situation regarding adolescent depression in the later stages of the pandemic remains unclear. This study investigated depressive symptoms status and changing trends among middle and junior high school students from 2019 to 2023.

Discovery of novel sulfonamide derivatives containing pinacolone moieties as fungicide candidates against Botrytis cinerea.

Background: Botrytis cinerea is one of the most serious plant diseases and severely threatens agricultural production. The rapidly intensifying resistance makes most commercial chemical fungicides lose control efficacy. Developing new fungicides with novel structures and modes of action is an effective measure to solve this problem.

Aspartate signalling drives lung metastasis via alternative translation.

Lung metastases occur in up to 54% of patients with metastatic tumours. Contributing factors to this high frequency include the physical properties of the pulmonary system and a less oxidative environment that may favour the survival of cancer cells. Moreover, secreted factors from primary tumours alter immune cells and the extracellular matrix of the lung, creating a permissive pre-metastatic environment primed for the arriving cancer cells.

Magnetic phase transition and spin-phonon coupling effect of antiferromagnetic NiO flakes probed by Raman spectroscopy.

Two-dimensional antiferromagnetic materials have attracted wide attention in both performance and application, which are of great significance for spin valves and next-generation magnetic random access memory devices. The spin-phonon coupling effect plays a crucial role in magnon dynamics. However, there is still a lack of research on the spin-phonon coupling effect of two-dimensional antiferromagnetic flakes.

QSAR-guided strategy for accurate annotation of FAHFA regioisomers.

Branched fatty acid esters of hydroxy fatty acids (FAHFAs) represent a novel class of bioactive lipids with significant physiological roles. However, their identification, particularly of low-abundance FAHFA regioisomers, remains challenging due to their high structural similarity, low natural abundance, and the limited availability of reliable FAHFA standards. In this study, we present a QSAR-based FAHFA annotation strategy that integrates a QSAR model with an ester bond position (EP) rule to determine the EPs of FAHFA regioisomers.