Publications by authors named "N Amudala"
Objective: Relapses are frequent and difficult to predict in antineutrophil cytoplasmic antibody-associated vasculitis (AAV), resulting in long-term use of immunosuppression. Although sinonasal disease is associated with relapse of AAV, detailed characterization of sinonasal symptoms is lacking. Using a patient-reported outcome, the 22-item SinoNasal Outcome Test (SNOT-22), we investigated the relationship between sinonasal symptoms and disease activity in AAV.
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- The study investigates the use of magnetic resonance imaging (MRI) to evaluate potential visual impairment in giant cell arteritis (GCA), even in patients who show no visual symptoms.
- Out of 64 patients suspected of having GCA, MRI detected significant orbital enhancement in many cases, indicating its effectiveness in diagnosing both ocular and nonocular GCA.
- Results showed that MRI enhancement correlated with inflammation levels and decreased post-treatment, prompting further research on MRI's role in identifying patients at lower risk for blindness who might require reduced glucocorticoid therapy.
Objectives: Rituximab is a standard of care therapy for patients with ANCA-associated vasculitis. When rituximab is contraindicated, or in the case of refractory disease, other treatments are needed. Obinutuzumab is another anti-CD20 antibody for the treatment of haematological malignancies that may induce a deeper B cell depletion compared with rituximab.
View Article and Find Full Text PDFBackground: Conventional treatment of eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss) with glucocorticoids, with or without additional immunosuppressive drugs, is limited by partial efficacy, frequent toxicity and a high relapse rate. Rituximab is a licensed treatment for granulomatosis with polyangiitis and microscopic polyangiitis and is of potential benefit to patients with EGPA.
Methods: Patients with EGPA who received rituximab as single or repeated courses were identified from four vasculitis centres.
Objective: Patients vary in their beliefs related to the cause of serious illness. The effect of these beliefs among patients with systemic vasculitis is not known. Our study aimed to describe causal attributions about disease onset and relapse in systemic vasculitis and to examine whether causal beliefs differ by type of vasculitis or are associated with negative health outcomes.
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