RS35705950 polymorphism of MUC5B Gene: Association with Rheumatoid Arthritis and Interstitial lung disease in Tunisian Population.

Introduction: Interstitial lung disease (ILD) is the most common extra-articular manifestation in rheumatoid arthritis (RA). Studies have concluded that there is an association between rs35705950 polymorphism of the MUC5B gene and RA-ILD.

Aim: To explore this polymorphism in a cohort of Tunisian patients suffering from RA with or without ILD and stufdy its association to ILD during RA.

Remediation of water containing lead(II) using (3-iminodiacetic acid) propyltriethoxysilane graphene oxide.

A novel chelating adsorbent based on (3-iminodiacetic acid) propyltriethoxysilane graphene oxide (IAT-GO) has been developed, showing exceptional promise for capturing lead. IAT-GO is made by combining a high-surface-area graphene oxide with a specially designed chelating ligand, which can selectively and efficiently remove lead. The synthesis of IAT-GO involves a two-step progression.

Autoantibodies Serum Level and 10-Year Risk of Fractures Evaluated by FRAX Tool in Rheumatoid Arthritis Patients.

Purpose: FRAX is a tool used for evaluation of risk of fracture in RA and non-RA patients and to identify those eligible for intervention. One of the limitations of FRAX in RA settings is that it does not consider factors known to contribute to osteoporosis such as autoantibodies. This study analysed the association of anti-mutated citrullinated vimentin antibody (anti-MCV), anti-cyclic citrullinated peptide antibody (anti-CCP), IgM rheumatoid factor (RF), IgA RF with 10-year risk of major osteoporosis and hip fracture.

A green bio-organic catalyst (taurine) promoted one-pot synthesis of (/)-2-thioxo-3,4-dihydropyrimidine(TDHPM)-5-carboxanilides: chiral investigations using circular dichroism and validation by computational approaches.

Owing to the massive importance of dihydropyrimidine (DHPMs) scaffolds in the pharmaceutical industry and other areas, we developed an effective and sustainable one-pot reaction protocol for the synthesis of (/)-2-thioxo-DHPM-5-carboxanilides the Biginelli-type cyclo-condensation reaction of aryl aldehydes, thiourea and various acetoacetanilide derivatives in ethanol at 100 °C. In this protocol, taurine was used as a green and reusable bio-organic catalyst. Twenty-three novel derivatives of (/)-TDHPM-5-carboxanilides and their structures were confirmed by various spectroscopy techniques.

Synthesis, anticancer activity and molecular docking of new quinolines, quinazolines and 1,2,4-triazoles with pyrido[2,3-] pyrimidines.

Recently, heterocyclic compounds such as pyrido [2,3-] pyrimidinones, 1,2,4-triazolopyrimidines, pyrimidoquinazolines, and quinoline derivatives have gained attention from researchers due to their pharmacological and biological activities. To synthesize new compounds, quinoline-2-thioxopyrido [2,3-] pyrimidinone and methylthioquinoline-pyrido [2,3-] pyrimidinones were used as starting materials. The new compounds synthesized were quinoline-pyrido [2,3-] (DeGoey et al.