Publications by authors named "N Amigo"
Vacuoleless Gametophytes (VLG) is a DC1 domain protein that was initially characterized as essential for early female and male gametophytes development in Arabidopsis. However, VLG expression was also detected in stamens, pistils and other sporophytic tissues, implying a broader role for this protein. As homozygous insertional VLG lines resulted unviable, we generated Arabidopsis amiRNA VLG knock-down plants to study the role of VLG in sporophyte development.
View Article and Find Full Text PDFBackground: Apolipoprotein (apo) C-III is involved in several processes that increase triglyceride levels, inflammation, and insulin resistance. Four of its proteoforms have been the focus of several studies and have shown differential associations with cardiovascular risk biomarkers, mostly lipids. However, there are other proteoforms of apoC-III that have not yet been investigated in detail.
View Article and Find Full Text PDFBackground: Obesity is a complex, diverse and multifactorial disease that has become a major public health concern in the last decades. The current classification systems relies on anthropometric measurements, such as BMI, that are unable to capture the physiopathological diversity of this disease. The aim of this study was to redefine the classification of obesity based on the different H-NMR metabolomics profiles found in individuals with obesity to better assess the risk of future development of cardiometabolic disease.
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- Rheumatoid arthritis (RA) is a chronic autoimmune disease linked to joint pain and disabilities, and ongoing research is examining its connection with cardiovascular (CV) disease.
- A study involving 219 RA patients, some with metabolic disorders, focused on measuring specific microRNAs and glycoproteins to understand their roles in inflammation related to RA and CV health.
- Findings revealed that RA patients had higher levels of glycoproteins compared to controls, which were correlated with inflammatory markers and certain miRNAs, suggesting that these glycoproteins may indicate RA severity and are related to both inflammation and CV disease.
: Mastitis is one of the main complications during breastfeeding and contributes to the cessation of breastfeeding. However, the etiopathogenesis and diagnosis of mastitis are complex and not yet well defined. We aimed to identify metabolic and lipidic changes in human milk during acute and subacute mastitis in order to detect potential biomarkers of mastitis.
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