Publications by authors named "N Almond"
Background: In a convenience sample of women scheduled for chemotherapy for early-stage breast cancer, we investigated associations of the Center for Disease Control and Prevention's neighborhood-level social vulnerability index (SVI) with pretreatment demographics and patient-reported outcome (PRO) measures (health behavior, function and quality of life, treatment toxicities during chemotherapy).
Methods: The SVI Overall score is comprised of 4 themes: socioeconomic, household composition, minority status/language, and household type/transportation, with scores ranging from 0 = lowest to 1 = highest vulnerability neighborhoods. Participant SVI scores were derived from zip codes listed in the patient's address within the electronic medical record (EMR).
Article Synopsis
- Chikungunya virus (CHIKV) is a virus transmitted by mosquitoes that causes severe joint pain and fever, continuing to cause outbreaks globally since 2005.
- To test potential vaccines and antivirals, researchers compared disease progression and viral loads in different mouse strains, focusing on A129 (which lacks a specific receptor) and C57BL/6.
- Findings showed that A129 mice experienced more severe disease compared to their parental 129Sv/Ev strain, and 129Sv/Ev mice had higher viral loads than C57BL/6, establishing important models for future research.
Article Synopsis
- * A new vaccine, ChAdOx1.COVconsv12, was created to enhance the immune response by targeting conserved viral regions, aiming to provide broader protection against various sarbecoviruses, including new variants of SARS-CoV-2.
- * In studies with mice and Syrian hamsters, while ChAdOx1.COVconsv12 alone didn't prevent SARS-CoV-2 infection, it improved recovery and reduced viral load when given alongside a smaller dose of the spike vaccine, indicating potential benefits
Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is spread by infected ticks or direct contact with blood, tissues and fluids from infected patients or livestock. Infection with CCHFV causes severe haemorrhagic fever in humans which is fatal in up to 83 % of cases. CCHFV is listed as a priority pathogen by the World Health Organization (WHO) and there are currently no widely-approved vaccines.
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