Effect of periodontal treatment on the clinical parameters of patients with rheumatoid arthritis: study protocol of the randomized, controlled ESPERA trial.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disorder that leads to joint damage, deformity, and pain. It affects approximately 1% of adults in developed countries. Periodontitis is a chronic oral infection, caused by inflammatory reactions to gram-negative anaerobic bacteria, and affecting about 35 to 50% of adults.

Impact of neurofibromatosis 1 upon quality of life in childhood: a cross-sectional study of 79 cases.

Background: Neurofibromatosis 1 (NF1) has a significant impact on quality of life (QoL).

Objectives: To evaluate QoL in NF1 according to phenotype from the viewpoint of children and proxy.

Methods: One hundred and forty families with a child aged between 8 and 16 years, seen consecutively at the National Academic Paediatric Referral Centre for NF1 for a phenotype evaluation, were contacted by mail.