Publications by authors named "N Alfaidy"
Am J Obstet Gynecol
October 2024
Article Synopsis
- * Researchers aimed to determine the role of antibody-dependent cell-mediated cytotoxicity (ADCC) in avelumab's effectiveness and whether variations in the FcγR3A receptor can predict patient responses.
- * Findings confirmed the presence of FcγR3A+ natural killer (NK) cells in PD-L1-expressing GTN, and that avelumab enhances NK cell activity, further suggesting higher affinity FcγR3A variants may
Hum Reprod Open
April 2024
Article Synopsis
- A study investigated the link between environmental chemicals, specifically phthalates, and changes in the placenta's weight, vascular resistance, and overall efficiency.
- Previous research on the effects of chemicals like phenols and phthalates on placental health has been limited and compromised due to inaccuracies in exposure measurement.
- This prospective study included a cohort of mothers and children, analyzing multiple urine samples from pregnant women to assess chemical exposure and its effects on placental parameters.
Methods Mol Biol
November 2023
Article Synopsis
- Normal fetal growth and placental development require active blood vessel formation (angiogenesis) at the mother-baby interface during pregnancy.
- Researchers have developed a new, noninvasive method to measure placental blood vessel growth in pregnant mice using a fluorescent molecule, Angiostamp700, that targets specific proteins found in developing blood vessels.
- This method allows for the quantification of angiogenic activity and provides insights into pregnancy outcomes without harming the mother or fetus.
Methods Mol Biol
November 2023
Article Synopsis
- Gestational trophoblastic diseases (GTD) include rare tumors related to pregnancy, with gestational choriocarcinoma (CC) being a highly aggressive type that can lead to high mortality if not treated quickly.
- CC has a higher incidence in molar pregnancies and poses greater risks in developing countries, with rates as high as 20 cases per 1,000 pregnancies.
- A new animal model for CC was created by injecting specific cancer cells into the placenta of pregnant mice, allowing researchers to mimic cancer development and metastasis, which highlights the role of placental blood vessels in spreading the tumor.
Article Synopsis
- Predicting spontaneous preterm birth is challenging for public health, especially in asymptomatic women.
- This study aimed to assess whether circulating levels of EG-VEGF can effectively predict preterm birth in women at high risk for placenta-related issues, using data from 200 patients.
- Results showed that women who experienced spontaneous preterm birth had significantly higher EG-VEGF levels at various points in pregnancy, suggesting that these levels could serve as a reliable biomarker for assessing this risk.
