Publications by authors named "N Alagna"

Motivation: Oxford Nanopore Technologies recently adopted the POD5 file format for storing raw nanopore sequencing data. The information stored in these files provides detailed insights into the sequencing features and enhances the understanding of raw nanopore data. However, the process of visualizing the data can be cumbersome, especially for users without programming skills.

View Article and Find Full Text PDF
Article Synopsis
  • The nuclear lamina (NL) is an essential part of the inner nuclear membrane made up of lamin filaments and proteins, crucial for maintaining the nucleus's structure and mechanical properties.
  • 'B-type' lamins are constantly present in all human cells, while 'A-type' lamins are specific to certain tissues and development stages, with unique functions in the nucleoplasm.
  • Recent research emphasizes the structural and regulatory aspects of lamin filaments, highlighting their roles in cell signaling, development, and their function as "mechanosensors" that connect cytoskeletal and nuclear structures.
View Article and Find Full Text PDF

Lamina-associated domains are large regions of heterochromatin positioned at the nuclear periphery. These domains have been implicated in gene repression, especially in the context of development. In mammals, LAD organization is dependent on nuclear lamins, inner nuclear membrane proteins, and chromatin state.

View Article and Find Full Text PDF

The introduction of N-heterocyclic carbene ligands has greatly increased the lifetimes of metal-to-ligand charge transfer states (MLCT) in iron(II) complexes, making them promising candidates for photocatalytic applications. However, the spectrally elusive triplet metal-centered state (MC) has been suggested to play a decisive role in the relaxation of the MLCT manifold to the ground state, shortening their lifetimes and consequently limiting the application potential. In this work, time-resolved vibrational spectroscopy and quantum chemical calculations are applied to shed light on the MCs' involvement in the deactivation of the MLCT manifold of an iron(II) sensitizer.

View Article and Find Full Text PDF

Singlet fission (SF) has the potential to boost solar energy conversion. Research has focused on designing new strategies to tune the electrochemistry, photophysics, and device architecture at the molecular level to improve the efficiency of SF sensitizers. These studies indicate that SF efficiency strongly depends on morphology, packing, and chemical structure.

View Article and Find Full Text PDF