Publications by authors named "N Aikawa"
Article Synopsis
- The study investigated the effectiveness of N-acetylcysteine (NAC) in relieving dryness symptoms in women with Sjögren's disease through a placebo-controlled trial with 60 participants.
- Results showed no significant improvements in dryness symptoms or oxidative stress levels with NAC compared to placebo at the 30 and 90-day marks, despite higher NAC blood concentrations in the treatment group.
- The findings suggest that while NAC can be taken as a rescue therapy for Sjögren's disease, it does not significantly alleviate symptoms of dryness or oxidative stress.
Objective: To evaluate the influence of environmental factors and prematurity relating to juvenile dermatomyositis (JDM), its course and refractoriness to treatment.
Methods: A case-control study with 35 patients followed up at a tertiary hospital and 124 healthy controls, all residents of São Paulo. Patients were classified according to monocyclic, polycyclic or chronic disease courses and refractoriness to treatment.
Long-Term Follow-Up of Anti-Infliximab Antibodies in Patients With Radiographic Axial Spondyloarthritis: A Marker of Drug Survival and Tapering.
Arthritis Rheumatol
October 2024
Objective: The aim of this study was to evaluate the influence of anti-infliximab (IFX) antibodies on three different points of care: response/tolerance to IFX, tapering strategy, and in a subsequent treatment with a second tumor necrosis factor inhibitor (TNFi).
Methods: A prospective cohort of 60 patients with radiographic axial spondyloarthritis who received IFX were evaluated retrospectively regarding clinical/laboratorial data, IFX levels, and anti-IFX antibodies at baseline, after 6, 12 to 14, 22 to 24, 48 to 54, 96 to 102 weeks, and before tapering or switching.
Results: Anti-IFX antibodies were detected in 27 patients (45%), of whom 23 (85.
Updates in the care and management of children and adolescents with systemic lupus erythematosus.
Curr Opin Rheumatol
September 2024
Purpose Of Review: This narrative review offers an update of the most important recent articles published in the previous year of childhood-onset systemic lupus erythematosus (cSLE), focusing on care and management.
Recent Findings: Age-related disparities may play a significant role in the clinical and laboratory characteristics of cSLE, as well as its performance in distinct classification criteria. Monogenic lupus is associated with higher disease damage scores and mortality rate compared to sporadic cSLE.
Introduction: Seasonal influenza A (H3N2) virus is an important cause of morbidity and mortality in the last 50 years in population that is greater than the impact of H1N1. Data assessing immunogenicity and safety of this virus component in juvenile systemic lupus erythematosus (JSLE) is lacking in the literature.
Objective: To evaluate short-term immunogenicity and safety of influenza A/Singapore (H3N2) vaccine in JSLE.