Immunotherapy for Type 1 Diabetes: Mechanistic Insights and Impact of Delivery Systems.

Type 1 Diabetes is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells, leading to hyperglycemia and various complications. Despite insulin replacement therapy, there is a need for therapies targeting the underlying autoimmune response. This review aims to explore the mechanistic insights into T1D pathogenesis and the impact of delivery systems on immunotherapy.

Fusion Free Median Corpectomy - Long-Term Consequence of Foregoing Fusion and Fixation: A Serendipitous Observation.

Background: Anterior cervical corpectomy and fusion (ACCF) involves placement of a graft/implant to ensure fusion and stabilization along with neural decompression. We share our experience with a subset of ACCF patients in whom graft/implant could not be placed post decompression for varying reasons but had a favorable long-term outcome. The necessity for routine fusion after corpectomy is critically analyzed, and the feasibility of an alternative surgical option without graft/implant is discussed.

An evaluation of haemodynamic responses to tracheal intubation following intravenous dexmedetomidine and fentanyl in patients undergoing laparoscopic cholecystectomy.

Background: Laryngoscopy and tracheal intubation are related to sympathetic stimulation and lead to hypertension and tachycardia. These changes in hemodynamics may increase the risk of myocardial ischemia. As a result, effective blunting of these unpleasant responses is required.

Manipulating Floquet-driven topological insulator with off-resonant elliptically polarized light in presence of hexagonal Fermi surface warping.

The irradiation of topological insulator surface with elliptically polarized light modifies the topological properties in a phase-dependent manner impacting the Floquet Chern number which is a crucial topological invariant associated with such driven systems. Employing Floquet theory in presence of hexagonal warping term in the Dirac fermion Hamiltonian under off-resonant conditions, we derive an effective Hamiltonian that highlights distinct features in the Floquet-Dirac surface states. Specifically, we identify a helicity and ellipticity-dependent mass term in the quasi-static Hamiltonian, breaking time reversal symmetry.

Pediatric firearm injuries and socioeconomic vulnerability before and during the COVID-19 pandemic.

Background: Pediatric firearm injuries disproportionately affect groups experiencing socioeconomic disadvantage. Firearm injuries increased during the COVID-19 pandemic, but the impact on communities by degree of socioeconomic disadvantage is unknown. We examined the association between socioeconomic vulnerability and change in pediatric firearm injuries before versus during the pandemic.