T-cell Engagers in Prostate Cancer.

Owing to the "cold" tumor immune microenvironment of prostate cancer, immune-targeting agents have shown limited efficacy in patients with advanced prostate cancer, highlighting the need for new therapies with novel mechanisms of action. In this context, T-cell engagers (TCEs), which induce T-cell-mediated killing of cancer cells by binding the CD3 receptor on T cells and a specific tumor antigen expressed on malignant cells, represent a promising therapeutic option. Multiple studies have explored the use of TCEs in previously treated patients with metastatic castration-resistant prostate cancer, and several ongoing trials are currently assessing novel TCEs either as single agents or in combinatorial regimens with molecules with a distinct mechanism of action (eg, androgen receptor pathway inhibitors and other immune-targeting agents).

Neuroprotective effects of gastrodin against bisphenol A induced-ADHD-like symptoms in rats.

Gastrodin (GAS) is a potent pharmaceutical compound extracted from the dried roots of a Chinese medicinal herb, Blume. It has been used as a neuroprotective treatment for a range of neurological disorders. Bisphenol A (BPA) has been implicated in the induction of attention-deficit hyperactivity disorder (ADHD)-like symptoms.

Unusual Cardiovascular Response to Sildenafil: Complete Heart Block in a Healthy Young Adult.

Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, is widely used for erectile dysfunction and pulmonary hypertension, with its cardiovascular safety profile being well documented. However, its potential to induce conduction abnormalities remains largely unexplored, both due to a lack of clinical reports and limited mechanistic studies. While tachyarrhythmias have been frequently associated with sildenafil use, bradyarrhythmias, particularly complete heart block, are an unreported complication.

Emergent spinal pathologies in late-term pregnancy.

Pregnancy-induced changes to spinal anatomy and physiology can increase the complexity of neurosurgical intervention in this population. There are numerous reports focused on the neurosurgical management of intracranial pathology for pregnant patients. However, less is known about the neurosurgical management of acute spinal pathology.

SwinConvNeXt: a fused deep learning architecture for Real-time garbage image classification.

Waste management handles all kinds of waste, including household, industrial, municipal, organic, biomedical, biological, and radioactive wastes. People still face challenges in proper disposal methods for different types of waste, including landfill-bound items, recyclable materials, and biodegradable waste. Inadequate waste management poses a significant and multifaceted global challenge.