Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential.

Malaria, caused by species and transmitted by mosquitoes, continues to pose a significant global health threat. Pipecolisporin, a cyclic hexapeptide isolated from , has emerged as a promising antimalarial candidate due to its potent biological activity and stability. This study explores the synthesis, antimalarial activity, and computational studies of pipecolisporin, aiming to better understand its therapeutic potential.

Non-communicable diseases and their associations with outpatient services utilisation: insight from a population-based survey in Malaysia.

Objectives: Multimorbidity has been recognised as a global public health issue, and individuals with multimorbidity have been found to have high healthcare utilisation. This study aims to estimate the prevalence of non-communicable diseases among adults in Malaysia, identify factors associated with multimorbidity, and assess the association between the number of non-communicable diseases and outpatient services utilisation.

Design And Setting: A retrospective secondary data analysis using data from the National Health and Morbidity Survey 2019, a cross-sectional household survey among the population in Malaysia.

Pediatric Mycosis Fungoides Mimicking Benign Dermatoses: A Report of a Rare Case.

BACKGROUND Primary cutaneous lymphomas (PCL) are a multifaceted spectrum of cutaneous T cell lymphoma (CTCL) and cutaneous B cell lymphomas (CBCL). Mycosis fungoides (MF) is a rare subset of CTCL that primarily affects adults, and its occurrence in children is exceedingly rare. Most pediatric MF manifests as hypopigmented patches resembling other benign dermatoses, causing diagnostic challenges.

Enrichment and characterization of foodborne fungal spores by ferric ion-based surface-assisted laser desorption/ionization mass spectrometry.

We developed a novel surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) method to detect fungal spores, which is a critical concern in food safety. A combination of Fe and trifluoroacetic acid (TFA) was initially confirmed as an effective light absorber, facilitating the desorption and ionization of small organics in SALDI-MS. This approach was then successfully applied to the analysis of small organics derived from Aspergillus niger, aflatoxigenic Aspergillus flavus, and non-aflatoxigenic A.