Publications by authors named "N Abdul Ghafar"
Article Synopsis
- * Using retrospective data from March 2019 to March 2022, researchers applied logistic regression analyses to identify factors linked to AR and patient deaths, highlighting that length of hospital stay and time were significant predictors.
- * The findings showed that while resistance in Gram-negative bacteria decreased during and after the pandemic, the overall prevalence of pan drug resistance reached 85.7% during the pandemic, with a sixfold increase in the odds of developing multi-drug resistance compared to other periods. *
Introduction: The occurrence of antibiotic resistance (AR) has become a critical issue during the Novel coronavirus disease 2019 (COVID-19) pandemic. This study explores the experiences of healthcare commissioners with AR during the COVID-19 pandemic, identifies challenges, and provides recommendations for combating AR during pandemics.
Methods: This qualitative study was multi-centered and used a phenomenological approach.
Millions who live in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections, which cause Chagas disease and human African trypanosomiasis (HAT). Improved HAT treatments are available, but Chagas disease therapies rely on two nitroheterocycles, which suffer from lengthy drug regimens and safety concerns that cause frequent treatment discontinuation. We performed phenotypic screening against trypanosomes and identified a class of cyanotriazoles (CTs) with potent trypanocidal activity both in vitro and in mouse models of Chagas disease and HAT.
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- During the COVID-19 pandemic, healthcare workers (HCWs) in Saudi Arabia exhibited significant overuse of antibiotics, which has contributed to increased antibiotic resistance (AR).
- A study assessing HCWs' knowledge, attitudes, and practices (KAP) on AR found that while they had a generally positive attitude, their actual knowledge and practices regarding the use of antibiotics were not as strong, with only half practicing appropriate antibiotic use.
- Factors influencing better KAP included nationality, age, healthcare qualifications, and job roles; however, many HCWs still mistakenly believed that antibiotics could treat COVID-19 infections.
Over the last several decades, numerous modifications and advancements have been made to design the optimal corneal biomatrix for corneal epithelial cell (CECs) or limbal epithelial stem cell (LESC) carriers. However, researchers have yet to discover the ideal optimization strategies for corneal biomatrix design and its effects on cultured CECs or LESCs. This review discusses and summarizes recent optimization strategies for developing an ideal collagen biomatrix and its interactions with CECs and LESCs.
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