Biocompatibility of Intensified Decellularized Equine Carotid Arteries in a Rat Subcutaneous Implantation Model and in a Human In Vitro Model.

Limited biocompatibility of decellularized scaffolds is an ongoing challenge in tissue engineering. We recently demonstrated that intensified detergent-based decellularization of equine carotid artery (dEAC) removed residual cellular molecules from the scaffold more efficiently than a conventional decellularization (dEAC), although this approach did not eliminate its immunogenicity entirely. CCN1 has been shown to improve biocompatibility of dEAC in a sheep model.