Publications by authors named "N A Yusof"

Pyrethroid pesticides are essential for modern agriculture, helping to control pests and protect crops. However, due to growing concerns about their potential impact on human health and the environment, reliable detection methods are essential to ensure food safety. In this literature review, we explore the techniques used over the past decade to detect pyrethroid residues in agricultural products.

View Article and Find Full Text PDF

Purpose: Reperfusion of the ischaemic heart is essential to limit myocardial infarction. However, reperfusion can cause cardiomyocyte hypercontracture. Recently, cardiac myosin-targeted inhibitors (CMIs), such as Mavacamten (MYK-461) and Aficamten (CK-274), have been developed to treat patients with cardiac hypercontractility.

View Article and Find Full Text PDF
Article Synopsis
  • An aptamer-ligand biorecognition system was developed to detect cyanide intoxication through its metabolite, 2-amino-2-thiazoline-4-carboxylic acid (ATCA).
  • Aptamers were identified from a DNA library using a technique called GO-SELEX, and their effectiveness was tested through molecular docking and thermodynamic analysis.
  • The resulting aptasensor, utilizing the best-performing aptamer (Apt46), demonstrated a low detection limit and high recovery rates across different biological samples, showing promise for use in acute cyanide exposure cases.
View Article and Find Full Text PDF

Introduction: The pathogenesis of nasopharyngeal carcinoma (NPC) is intricate, influenced by a combination of factors including host genetics, viral infection and environmental elements, resulting in genetic and epigenetic modifications. Despite a positive prognosis for early-stage patients, most NPC cases are diagnosed at an advanced stage, highlighting the pressing need for enhanced accessibility to early diagnosis and treatment. The underlying molecular pathways driving NPC progression remain elusive.

View Article and Find Full Text PDF

Talaromyces marneffei is a thermally dimorphic fungus which causes opportunistic infections in immunocompromised individuals. The diagnosis of T. marneffei infection rests on the microscopic demonstration of the fungus in the tissues and/or isolation of the fungus from clinical specimens.

View Article and Find Full Text PDF