Modulation of γδ T cells by USF3: Implications for liver fibrosis and immune regulation.

Previous studies have established that γδ T cells play a significant role in liver fibrosis. However, their specific functions and mechanisms in fibrotic liver tissue remain unclear. Using online microarray expression profiles, we observed that USF3 was upregulated in patients with liver fibrosis and was associated with immune cells.

HDAC3 and Snail2 complex promotes melanoma metastasis by epigenetic repression of IGFBP3.

The treatment of metastatic melanoma has long posed a complex challenge within clinical practice. Previous studies have found that EMT transcription factors are essential in the development of various cancers through their induction of EMT. Here, we demonstrate that Snail2 expression is dramatically increased in melanoma and is associated with an adverse prognosis.

Solvent-dripping modulated 3D/2D heterostructures for high-performance perovskite solar cells.

The controlled growth of two-dimensional (2D) perovskite atop three-dimensional (3D) perovskite films reduces interfacial recombination and impedes ion migration, thus improving the performance and stability of perovskite solar cells (PSCs). Unfortunately, the random orientation of the spontaneously formed 2D phase atop the pre-deposited 3D perovskite film can deteriorate charge extraction owing to energetic disorder, limiting the maximum attainable efficiency and long-term stability of the PSCs. Here, we introduce a meta-amidinopyridine ligand and the solvent post-dripping step to generate a highly ordered 2D perovskite phase on the surface of a 3D perovskite film.

Assessment of Self-Activation and Inhibition of Wheat Coiled-Coil Domain Containing NLR Immune Receptor Yr10.

Plant immunity is largely governed by nucleotide-binding leucine-rich repeat receptor (NLR). Here, we examine the molecular activation and inhibition mechanisms of the wheat CC-type NLR , a previously proposed candidate for the resistance gene. Though recent studies have identified as the true gene, Yr10 remains an important NLR in understanding NLR-mediated immunity in wheat.

Curvature Determination Method for Diverging Acoustic Lens of Underwater Acoustic Transducer.

Underwater acoustic transducers need to expand the coverage of acoustic signals as much as possible in most ocean explorations, and the directivity indicators of transducers are difficult to change after the device is packaged, which makes the emergence angle of the underwater acoustic transducer limited in special operating environments, such as polar regions, submarine volcanoes, and cold springs. Taking advantage of the refractive characteristics of sound waves propagating in different media, the directivity indicators can be controlled by installing an acoustic lens outside the underwater acoustic transducer. To increase the detection range of an underwater acoustic transducer in a specific marine environment, a curvature-determining method for the diverging acoustic lens of an underwater acoustic transducer is proposed based on the acoustic ray tracing theory.