Effect of electroacupuncture on vascular remodeling in rats with cerebral ischemia by regulating irisin based on VEGF/Akt/eNOS signaling pathway.

Objective: This study aimed to explore the cumulative effects and expression patterns of electroacupuncture (EA) on irisin secretion, observe the effects of EA on the recovery of neurobehavioral function and vascular remodeling after cerebral ischemia, and elucidate the mechanism by which EA promotes vascular remodeling by regulating irisin expression.

Methods: A rat model of left middle cerebral artery occlusion (MCAO) was prepared, and EA was performed. Tissue distribution and expression of irisin were determined by immunofluorescence, enzyme-linked immunosorbent assay (ELISA), and Western blotting.

Long-term changes in frailty and incident atrial fibrillation, heart failure, coronary heart disease, and stroke: A prospective follow-up study.

Background: People with frailty have increased prevalence and incidence of atrial fibrillation (AF).

Objective: The study aimed to further investigate the association of long-term changes in frailty with risk of new-onset AF. Its associations with heart failure (HF), coronary heart disease (CHD), and stroke were also evaluated as a secondary aim.

Hydroxysafflor yellow A attenuates the inflammatory response in cerebral ischemia-reperfusion injured mice by regulating microglia polarization per SIRT1-mediated HMGB1/NF-κB signaling pathway.

Background: Hydroxysafflor yellow A (HSYA), an active component isolated from Carthamus tinctorius L., has demonstrated potent protective effects against cerebral ischaemia/reperfusion (I/R) injury. Microglial polarisation plays a crucial role in I/R.

Intensifying Stabilization and Dissolution Capacity of Polyacrylamide Emulsion Drag Reducers Using a pH-Switchable Four-Tailed Ionic Liquid Surfactant.

To balance the stability and dissolution of polyacrylamide (PAM), emulsion drag reducers dominate the successful operation of volumetric fracturing. Herein, a pH-switchable four-tailed ionic liquid surfactant (OA/Cyclen) is synthesized by oleic acid (OA) and 1,4,7,10-tetraazacyclododecane (Cyclen). The four-tailed structure of OA/Cyclen enhances the stability of the emulsion polymerization reactor and supplies enough switchable sites for triggering the intensified release of the PAM emulsion.

Study on the Mechanism of Energy Dissipation in Hemispherical Resonator Gyroscope.

The hemispherical resonator gyroscope is a gyroscope based on the principle of Coriolis vibration, widely used in inertial measurement systems of spacecraft. This article decomposes the gyroscope into two parts: the resonator shell and the gyroscope head, establishes the energy dissipation mechanism of the gyroscope, and conducts experimental verification. Firstly, based on the working principle of the gyroscope, a mechanical analysis model of the hemispherical resonator gyroscope head with a resonator spherical shell containing quality defects under second-order vibration state was established.