[Hypoinsulinemia and lipid peroxidation in emotional-pain stress].

The development of emotional pain stress in rats is accompanied by an increase in lipid peroxidation (LPO) products in the pancreas and a decrease in antiradical activity of its lipids. Hypoinsulinemia, of which a degree of expression is inversely proportional to an increase in peroxidation products, is observed. Antioxidant administration prevents LPO process activation in the pancreas and inhibits, to a great extent, a decrease in the level of insulin in stress.

[Effect of lipid peroxidation on the insulin receptor in rat adipocytes].

Lipid peroxidation is studied for its effect on insulin receptors in isolated rat adipocytes. The results suggest that addition of two peroxidants (3 mM cumene hydroperoxide and 0.2 mM Fe2+) leads to malondialdehyde accumulation and binding inhibition through insulin receptors quantity and affinity decrease.

[Lipid peroxidation in the liver of rats with alloxan diabetes].

Experiments on white male rats were performed to study lipid peroxidation in the rat liver at varying times of the development of alloxan diabetes. After administering alloxan in a dose of 16 mg/100 g bw both non-enzymatic and enzymatic lipid peroxidation in the liver was substantially activated, while the blood glucose level ascended. Injection of insulin to rats with alloxan diabetes entailed a reduction of the blood glucose content and the formation of the final product of lipid peroxidation, malonic aldehyde (during non-enzymatic process).