Publications by authors named "N A Swanson"
Underrepresented populations' participation in clinical trials remains limited, and the potential impact of genomic variants on drug metabolism remains elusive. This study aimed to assess the pharmacokinetics (PK) and pharmacogenomics (PGx) of ribociclib in self-identified Black women with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2) advanced breast cancer. LEANORA (NCT04657679) was a prospective, observational, multicenter cohort study involving 14 Black women.
View Article and Find Full Text PDFArticle Synopsis
- Underrepresented groups continue to face challenges in participating in clinical trials, specifically regarding the effects of genetic variations on how drugs are processed in the body.
- This study focused on the pharmacokinetics and pharmacogenomics of the medication ribociclib in Black women with advanced breast cancer, revealing a mix of metabolizer types among participants.
- No significant differences were found in drug exposure or adverse events across different metabolizer groups, highlighting the need for further research and inclusion of diverse populations in clinical trials for more equitable healthcare outcomes.
Schooling fish rely on a social network created through signaling between its members to interact with their environment. Previous studies have established that vision is necessary for schooling and that flow sensing by the lateral line system may aid in a school's cohesion. However, it remains unclear to what extent flow provides a channel of communication between schooling fish.
View Article and Find Full Text PDFAs per the National Survey on Drug Use and Health, 10.5% of Americans aged 12 years and older are suffering from alcohol use disorder, with a wide range of neurological disorders. Alcohol-mediated neurological disorders can be linked to Alzheimer's-like pathology, which has not been well studied.
View Article and Find Full Text PDF