[Early encounters of German-language explorers with the Tibetan medicine in Siberia in the modern era].

The spreading of Tibetan Buddhism and with it the Tibetan medicine in the region east of Lake Baikal, goes back to the 17th century. At the beginning of the 18th century, German speaking scholars were among the first to undertake scientific expeditions through Siberia. As such they were amongst the first scientists of the modern era who encountered the traditions, concepts, and therapeutic methods of Tibetan medicine.

[Influence of selection on the sensitivity of laboratory mice to the cytogenetic effect oof thioTEPA].

The influence of selection and inbreeding on the sensitivity of laboratory mice to cytogenetic effect of thioTEPA was studied. Selection was started among genetically heterogenous "synthetic" population. The sensitivity of mice was estimated by the frequency of bone marrow cells with chromosome damages in males 24 hours after the treatment with 5 mg/kg of thioTEPA dose intraperitoneally.

[Chromosome aberrations induced by cyclophosphamide in the meiotic cells of male mice].

Cyclophosphamide was given intraperitoneally in doses of 40, 80 and 160 mg/kg to C57BL/6 male mice. Cytogenetic effect in spermatogonia of A and B types and in pachytene spermatocytes was studied by the frequencies of chromosomes recorded in cells at the stage of diakinesis MI meiosis. In some cells cyclophosphamide induced structural chromosomal aberrations, including translocations and the disturbances of normal bivalent formation.

Cyclophosphamide-induced chromosomal aberrations in meiotic cells of male mice.

Single doses of 40, 80 and 160 mg of cyclophosphamide per kg body weight were administered intraperitoneally to C57BL/6 male mice. Cytogenetic analysis of spermatocytes at diakinesis/metaphase I, influenced as spermatogonia A and B and pachytene spermatocytes, showed the chromosomal damage. Cyclophosphamide induced structural chromosomal aberrations including translocations and interfered with the normal development of bivalents.

[WR, a new strain of mice, highly sensitive to the cytogenetic effect of thiotepa].

Mice of the WR strain (genotype -aa, +WY) were selected for the appearance of black spots with normal pigmentation, presumably due to genetic recombination in the W gene region. The frequency of heterozigotes +WY with black spots was 25% in the 11th generation. The cytogenetic effect of thioTEPA (dose 5 mg/kg) was investigated in bone marrow cells of C57BL/10 NZW, 101/H and 129/Re mice.