Evaluation of a novel heparin-iloprost-based antithrombotic formulation blood collection tube for clinical usage.

Background: The objective of our study was to evaluate a single blood collection tube with a novel antithrombotic formulation to measure both hematological, biochemical, and d-dimer analytes.

Methods: Paired samples of gold standard blood tubes (EDTA, lithium heparin, sodium citrate) and a new antithrombotic formulation blood tube were collected from 187 patients. The new antithrombotic tube is a lithium heparin tube preloaded with a liquid form of prostacyclin analog.

Unboxing the digital forensic investigation process.

As digital forensics continues to play an important role in criminal investigations, its investigative work must be underpinned with well-defined and robust methodologies. Over the last 20 years, a substantial body of research has been produced to define and codify the digital forensic investigation process and the stages/sub-processes involved. Whilst current digital forensic investigation process models provide a solid foundation, it is argued that existing attempts often only focus on those physical tasks, which a practitioner must carry out at any given stage of an examination, omitting to identify those core thought processes, decisions and behaviours that form part of effective investigative practices.

What does a digital forensics opinion look like? A comparative study of digital forensics and forensic science reporting practices.

This study explores digital forensics (DF) reporting practices and compares the results with other forensic science disciplines. Forty reports were obtained from a quasi-experiment involving DF examiners, and a quantitative content analysis was performed to determine which conclusion types they applied and which content they included with relevance to the credibility of the reported results. A qualitative analysis was performed to examine the certainty expressions used in the conclusions.

Proteins of the Lectin Pathway of complement activation at the site of injury in subarachnoid hemorrhage compared with peripheral blood.

Background: A subarachnoid hemorrhage (SAH) is a debilitating stroke. Activation of the lectin pathway (LP) of the complement system in SAH patients could worsen the prognosis; however, conflicting results have been reported. This potentially reflects that pathological changes at the site of injury are not reflected in peripheral blood.

Plasma Neurofilament Light Chain Is Associated with Poor Functional Outcome and Mortality Rate After Spontaneous Subarachnoid Hemorrhage.

The initial clinical status after subarachnoid hemorrhage (SAH) is an important outcome predictor, but the mechanisms behind the early brain injury (EBI) remains incompletely understood. Elevated neurofilament levels in the cerebrospinal fluid at protracted stages after SAH are associated with poor outcome, but the potential association between plasma neurofilament (pNfL) levels during EBI, disease severity on admission, and poor outcome remains unaddressed. Plasma NfL (pNfL) was measured by single molecule array in 44 SAH patients on admission and 24 h after ictus, as well as in 44 controls.