Publications by authors named "N A Solomatina"
Article Synopsis
- Pulmonary issues in systemic juvenile idiopathic arthritis (SJIA) are uncommon but pose serious risks, with various known risk factors, including macrophage activation syndrome and specific immune responses.
- A study examined the characteristics and outcomes of SJIA patients with respiratory system involvement (RSI), finding that 25% showed signs of RSI at the onset, which was associated with more severe symptoms and complications.
- Among those with RSI, 10% later developed fibrosing interstitial lung disease (ILD), and patients showed a high prevalence of severe relapsed disease and a need for careful monitoring and management of their condition.
Background: Lung damage in systemic juvenile arthritis (sJIA) is one of the contemporary topics in pediatric rheumatology. Several previous studies showed the severe course and fatal outcomes in some patients. The information about interstitial lung disease (ILD) in the sJIA is scarce and limited to a total of 100 cases.
View Article and Find Full Text PDFJuvenile idiopathic arthritis with systemic onset with inflammatory bone lesions: two case reports of patients successfully treated with canakinumab and experience gained from literature.
Front Pediatr
May 2023
Unlabelled: Non-bacterial osteomyelitis (NBO) is a rare chronic inflammatory bone disease related to immune system dysregulation. This disease belongs to a family of autoinflammatory diseases. It often coexists with other TNF-α-mediated immune-mediated diseases such as juvenile idiopathic arthritis (JIA) and inflammatory bowel diseases.
View Article and Find Full Text PDFOne of the systems that regulate tissue homeostasis is gap junction intercellular communication (GJIC). It is accepted that the down-regulation of GJIC is linked to the tumor-promoting properties of carcinogens. In this study, the effect of some carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons (PAH) on GJIC was investigated.
View Article and Find Full Text PDFWe have studied the effect of polycyclic aromatic hydrocarbons (PAH) on gap junction intercellular communications (GJIC) in culture of hepatoma cells Hep G2 and G27. Carcinogenic PAH inhibited GJIC in both cultures in contrast to non-carcinogenic PAH. We showed that both constitutive and inducible expressions of mRNAs of Ah receptor and cytochrome P4501A1 (the main isoform involved in PAH metabolism) were absent in hepatoma G27 cells.
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