Highly energetic -cyano-substituted CL-20 analogues: challenging the stability limits of polynitro hexaazaisowurtzitanes.

To design high-energy-density materials of a new level, it is necessary to develop methods for the functionalization of energetic scaffolds, which will make it possible to tune their physicochemical and energetic properties. For this reason, we have elaborated an approach for synthesizing a new series of energetic cage compounds with advanced properties by introducing the -cyano group into the polynitro hexaazaisowurtzitane framework. The structures of the obtained substances were fully characterized with a combination of methods, including multinuclear (H, C{H}, N, and N{H}) NMR and IR spectroscopy, high-resolution mass spectrometry, X-ray diffraction analysis, electron microscopy and quantum chemical calculations.

Absent Diurnal Variation in Serum Testosterone in Young Men with Testosterone Deficiency.

Purpose: Although healthy young men demonstrate a diurnal pattern of serum testosterone, minimal information is available on diurnal variation in young men with testosterone deficiency.

Materials And Methods: Blood samples were obtained during a 24-hour period at 8 and 11 a.m.

Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics.

Otits media (OM) is the most frequent indication for antimicrobial prescription to US children. Streptococcus pneumoniae (S. pneumoniae) remains one of the most common pathogens causing OM.

Treatment of otitis media by transtympanic delivery of antibiotics.

Otitis media is the most common reason U.S. children receive antibiotics.

[Treatment of mild and moderate hypertension with enalapril (multicenter study of enap and enap N in Ukraine)].

Aim: Assessment of efficiency and safety of enalapril (enap) and its combination with hydrochlorotiaside (enap-N).

Materials And Methods: 127 patients with mild and moderate blood hypertension entered an open non-comparative multicenter trial. 60 of them received enap (group 1), 67--enap N (group 2).