Publications by authors named "N A Shlobin"
Background And Objectives: There is a paucity of data directly comparing the outcome of surgical techniques available for the treatment of hypothalamic hamartomas (HHs). This study aims to evaluate the safety and efficacy of commonly used surgical approaches in the treatment of HH-related epilepsy.
Methods: A systematic review and individual participant data (IPD) meta-analysis was conducted.
Article Synopsis
- Five billion people globally lack access to safe surgical care, with the greatest need in low- and middle-income countries like Moldova, particularly in specialized fields like neurosurgery.
- The history of neurosurgery in Moldova dates back to Soviet times, with its integration into the national health system beginning in the 1940s and the establishment of the first department in 1999.
- The article outlines the current state of neurosurgery in Moldova, noting the presence of eleven hospitals providing services, a growing number of female residents in training, and the availability of advanced imaging technology, while offering recommendations for improving neurosurgical care in underserved areas.
Article Synopsis
- People with epilepsy face risks of premature death, particularly through sudden unexpected death in epilepsy (SUDEP), sudden cardiac death (SCD), and sudden arrhythmic death syndrome (SADS), which share overlapping causes and mechanisms.
- Sudden death classification relies on autopsy findings and clinician expertise, with definitions for SUDEP, SCD, and SADS often leading to diagnostic confusion; most SUDEP cases do not involve seizure-induced arrhythmias.
- Effective risk assessment for sudden death in epilepsy requires a collaborative approach, including thorough clinical evaluations, toxicological tests, genetic analysis, and post-mortem examination, with future research aimed at refining the understanding and management of these conditions.
Importance: How epilepsy may promote cardiovascular disease remains poorly understood.
Objective: To estimate the odds of new-onset cardiovascular events (CVEs) over 6 years in older people with vs without epilepsy, exploring how enzyme-inducing antiseizure medications (EIASMs) and traditional cardiovascular risk factors mediate these odds.
Design, Setting, And Participants: This was a prospective cohort study using the comprehensive cohort of the Canadian Longitudinal Study on Aging (CLSA), with 6 years of follow-up (2015-2021, analysis performed in December 2023).